Cefepime

Restricted
C difficile risk
High
Oral Bioavailability
N/A

Spectrum Of Activity

Dosing

40 kg and less:
IV/IM 100mg/kg/DAY divided q12h. Max: 2g/dose.40 kg and greater:
IV/IM 1-2g q12h Febrile Neutropenia:
IV/IM 150mg/kg/DAY divided q8h. Max: 2g/dose

PNA <14 days:
IV: 60-100mg/kg/DAY divided q12hPNA 14 days or older:
IV 100mg/kg/DAY divided q12h

Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing.

General Information

Broad spectrum antimicrobial with gram positive and gram negative coverage including Pseudomonas.

Used especially nosocomial infections involving resistant organisms

  • Allergy (immediate or delayed).

  • Can cause positive Coombs, cytopenias.

Antimicrobial class: 4th generation Cephalosporin

Average serum half life:

  • Neonates: 4-5hours.

  • Children 2 months to 6 years: 1.77-1.96 hours.

  • Adult: 2 hours

Route of Elimination: At least 85% eliminated as unchanged drug in urine