15 mg/kg/DAY divided q12h. Max: 500mg/dose.
15 to 30 mg/kg/DAY divided q12h. Max: 500mg/dose.
Adjustment not needed as long as renal function is normal
Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing.
CAP, Pertussis, URTI, H. pylori, and mycobacterial infections
Monitor QTc in patients with increased risk
GI upset, diarrhea
Prolongation of QTc interval
Substrate of CYP3A4.
Multiple CYP450 interactions possible - consult a pharmacist for more detail. May increase digoxin, carbamazepine level. Use caution with QTc prolonging medications.
Antimicrobial class: Macrolide
Average serum half life:
Clarithromycin: 3-7 hours
14-OH-clarithromycin (active metabolite): 5-9 hours
Route of Elimination: Urine (20-40% as unchanged drug, additional 10%-15% as active metabolite); feces (29% to 40% mostly as metabolites)