Cloxacillin

C difficile risk
Medium
Oral Bioavailability
Moderate

Dosing

IV/IM 100-200mg/kg/DAY divided q4-6h. Max: 12g/DAY.PO 50-150mg/kg/DAY divided q6h. Max: 6g/DAY

0 - 1.2 kg1.2 - 2.0 kg2.0+ kgIV 25-50mg/kg/DOSE q12hIV 25-50mg/kg/DOSE q12hIV 25-50mg/kg/DOSE q8h

0 - 1.2 kg1.2 - 2.0 kg2.0+ kgIV 25-50mg/kg/DOSE q8-12hIV 25-50mg/kg/DOSE q8hIV 25-50mg/kg/DOSE q6h

Give oral dose on empty stomach. Oral liquid is not palatable. Consider oral cephalexin as alternative.

General Information

Treatment of sensitive MSSA and CoNS infections

Renal and hepatic function, CBC with differential, diarrhea

  • allergy (immediate or delayed)

  • phlebitis (IV)

  • cytopenias

  • eosinophilia

  • interstitial nephritis

  • abnormal liver enzymes

Antimicrobial class: Antistaphylococcal penicillin

Average serum half life: Adults:0.5-1.5 h (prolonged in renal impairment and in neonates)

Route of Elimination: urine and feces