3 months-12 years: IM/IV 30 mg/kg/DAY divided q12h
12 years & up: IM/IV 1000mg/DAY given as a single daily dose. Max: 1000mg/DAY
Safety and efficacy of ertapenem in neonates have not been established, therefore dosages are not available.
Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing.
Targeted therapy of ESBL infections and other resistant gram negative infections
Empiric therapy when broad spectrum of carbapenems is desired without the need for anti-pseudomonal activity
Renal and hepatic function, CBC
Immediate and delayed-type allergy
Cytopenias, eosinophilia, positive Coombs
Liver enzyme abnormalities
Valproic acid - carbapenems decrease valproate levels and may decrease seizure threshold.
ID consult recommended
Antimicrobial class: Carbapenem
Average serum half life:
Infants 3 months and older, and children: 2.5hrs
Adolescents and Adults: 4 hrs
Route of Elimination:
Non-CYP-mediated hydrolysis to inactive metabolite
Urine (80%(38% as unchanged drug)) and feces (10%)