Antimicrobials
Gentamicin

Gentamicin

Low
N/A

General Information

Enhanced nephrotoxic effect with concomitant use of other nephrotoxins.

Enhanced ototoxicity with loop diuretics (e.g. furosemide).

Non-depolarizing muscle relaxants may be potentiated.

Antimicrobial class: Aminoglycoside

Average serum half life:

  • Neonates: 3-11.5 hours
  • Infants: 4 ± 1 hour
  • Children: 2 ± 1 hour
  • Adolescents:1.5 ± 1 hour
  • Adolescents: 1.5 ± 1 hour
  • Adults: 1.5- 3 hours; End stage renal disease: 30-70 hours

Route of Elimination: Almost completely by glomerular filtration of unchanged drug with excretion into urine