Gentamicin
Neonatal

Neonatal

Any post-conceptual age at high risk for Gentamicin toxicity

Including
  • Weight less than or equal to 1250g
  • Hypoxic ischemic encephalopathy
  • Concurrent nephrotoxic medications
  • Concurrent indomethacin/ibuprofen
  • Hemodynamic instability, and/or
  • Renal dysfunction at start of therapy (urine output less than 1mL/kg/hr OR Scr increase of 30% or more from baseline or expected baseline)
  • Intrauterine growth restriction (IUGR); Consider contacting pharmacist for further guidance on dosing
All PNA with above risk factors

5mg/kg/DOSE IV q48h

Post conceptual age less than or equal to 29 weeks

All PNA

5mg/kg/DOSE IV q48h

Post conceptual age greater than 29 weeks to less than 35 weeks

PNA less than or equal to 7 days

5mg/kg/DOSE IV q36h

PNA greater than 7 days

5mg/kg/DOSE IV q24h

Post conceptual age greater than or equal to 35 weeks

All PNA

5mg/kg/DOSE IV q24h