Exceptions to use of extended interval dosing
Renal dysfunction at baseline; consider alternate antibiotic; CNS Infections, Endocarditis.
Synergistic dosing of aminoglycosides with beta-lactams; use conventional dosing.
Infants and Children: 4-7mg/kg/DOSE IV q24h
All Ages: 10-12mg/kg/DOSE IV q24h
Infants and Children: 2-2.5 mg/kg/DOSE IV q8h
IV, IM: Usually require higher doses at 2.5 to 3.3 mg/kg/DOSE every 6 to 8 hours
Synergistic dosing of aminoglycosides with beta-lactams
Use low doses of 1 mg/kg/DOSE every 8 hours
Treatment of Enterococcus species
May require synergistic therapy with a full dose of 2.5 mg/kg/DOSE every 8 hours