Children 6 months to 5 years of age: 16-20 mg/kg/DAY IV/PO divided q12h.Children greater than 5 years of age: 10 mg/kg/DAY IV/PO as a single daily dose; maximum dose: 750 mg
Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing.
Dosing for oral and IV levofloxacin is identical
Not to be given IM or SC administration.
Lower respiratory infection (CAP, HAP), intraabdominal infection
Monitor QTc in patients with increased risk
Dizziness, insomnia, rash, n/v, abdominal pain.
Tendinopathy and rupture, retinal detachment, peripheral neuropathy & QTc prolongation have been reported.
Increased risk when combined with other QTc prolonging agents.
AVOID concomitant administration with antacids, multivitamin & mineral supplements. Space doses by 2 hours.
Increased risk of tendon rupture with concomitant use of corticosteroids.
Monitor INR with warfarin.
Antimicrobial class: Fluoroquinolone
Average serum half life:
Infants ≥6 months to 5 years: ~4 hours.
Children 5-16 years: 4.8-6 hours.
Adults: 6-8 hours
Route of Elimination: 87% excreted unchanged in urine over 48 hours by tubular secretion and glomerular filtration; 4% in feces