Children 6 months to 5 years of age: 16-20 mg/kg/DAY IV/PO divided q12h.Children greater than 5 years of age: 10 mg/kg/DAY IV/PO as a single daily dose; maximum dose: 750 mg
Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing.
Dizziness, insomnia, rash, n/v, abdominal pain.
Tendinopathy and rupture, retinal detachment, peripheral neuropathy & QTc prolongation have been reported.
Increased risk when combined with other QTc prolonging agents.
AVOID concomitant administration with antacids, multivitamin & mineral supplements. Space doses by 2 hours.
Increased risk of tendon rupture with concomitant use of corticosteroids.
Monitor INR with warfarin.
Antimicrobial class: Fluoroquinolone
Average serum half life:
Infants ≥6 months to 5 years: ~4 hours.
Children 5-16 years: 4.8-6 hours.
Adults: 6-8 hours
Route of Elimination: 87% excreted unchanged in urine over 48 hours by tubular secretion and glomerular filtration; 4% in feces
