LevoFLOXacin

C difficile risk
High
Oral Bioavailability
N/A

Dosing

Children 6 months to 5 years of age: 16-20 mg/kg/DAY IV/PO divided q12h.Children greater than 5 years of age: 10 mg/kg/DAY IV/PO as a single daily dose; maximum dose: 750 mg

Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing.

Dosing for oral and IV levofloxacin is identical

Not to be given IM or SC administration.

General Information

Lower respiratory infection (CAP, HAP), intraabdominal infection

Monitor QTc in patients with increased risk

Dizziness, insomnia, rash, n/v, abdominal pain.

Tendinopathy and rupture, retinal detachment, peripheral neuropathy & QTc prolongation have been reported.

Increased risk when combined with other QTc prolonging agents.

AVOID concomitant administration with antacids, multivitamin & mineral supplements. Space doses by 2 hours.

Increased risk of tendon rupture with concomitant use of corticosteroids.

Monitor INR with warfarin.

Antimicrobial class: Fluoroquinolone

Average serum half life:

  • Infants ≥6 months to 5 years: ~4 hours.

  • Children 5-16 years: 4.8-6 hours.

  • Adults: 6-8 hours

Route of Elimination: 87% excreted unchanged in urine over 48 hours by tubular secretion and glomerular filtration; 4% in feces