Penicillin G (parenteral)

C difficile risk
Low
Oral Bioavailability
N/A

Dosing

100,000 to 250,000 units/kg/DAY divided q6h. Max 8 million units/DAY.

250,000 to 400,000 units/kg/DAY divided q4h. Max 24 million units/DAY.

0 - 2 kg2+ kgIV, IM 50,000-100,000 units/kg/DAY divided q12hIV, IM 75,000 -150,000 units/kg/DAY divided q8h

0 - 2 kg2+ kgIV, IM 75,000 -150,000 units/kg/DAY divided q8hIV, IM 100,000 - 200,000 units/kg/DAY divded q6h

PNA-days 0 - 7PNA-days 8+ IV: 250,000 to 450,000 units/kg/DAY divided q8hIV: 450,000 to 500,000 units/kg/DAY divided q6h

Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing.

General Information

Therapy of Streptococcal and other documented susceptible infections, syphilis

Renal and hepatic function, CBC with differential, hypersensitivity reactions and IV site for phlebitis.

Allergy/rash (immediate or delayed), seizures, cytopenias, eosinophilia, interstitial nephritis, abnormal liver enzymes, serum sickness

Antimicrobial class: penicillin

Average serum half life:

  • Neonates: <6 days: 3.2 to 3.4 hours. 7 to 13 days: 1.2 to 2.2 hours. >14 days: 0.9 to 1.9 hours.

  • Pediatrics: 0.5-1.2 hours.

  • Adults normal renal function: 30- 50 mintes

Route of Elimination: Renal (58% to 85% unchanged drug)