Infants and Children <12 years: 25-75 mg/kg/DAY PO divided q6-8h. Max 2000 mg/DAY.Children >12 years and Adolescents: 375-2000 mg/DAY PO divided q6-8h or dose based on weight: 25- 75 mg/kg/DAY PO divided q6-8h.Prophylaxis for asplenia (Infants and children <3 years), PO: 250 mg/DAY divided into 2 daily dosesProphylaxis for asplenia (children ≥3 years), PO: 500 mg/DAY divided into 2 daily doses.
No dose adjustment recommended.
Use with caution; excretion is prolonged in patients with renal impairment. Consult with a pharmacist for dosing in renal impairment.
Streptococcal infections and therapy of documented susceptible infection not requiring parenteral therapy (i.e. upper respiratory tract)
Prophylaxis after rheumatic fever
Monitor for allergy.
Periodic CBC, SCr
Allergy (anaphylaxis) and other rash
Cytopenias, Positive Coombs, Eosinophilia
Acute interstitial nephritis
Antimicrobial class: Penicillin
Average serum half life: No pediatric data. Adults: 30 minutes; prolonged in patients with renal impairment
Route of Elimination: Penicillin V and its metabolites are excreted in urine