Tobramycin - Neonatal Dosing

Exceptions to use of extended interval dosing: Renal dysfunction at baseline; consider alternate antibiotic
Synergistic dosing of aminoglycosides with beta-lactams; use conventional dosing.

Any gestation, if on indomethacin, with RDS, or asphyxia or renal impairment:
5 mg/kg/DOSE q48h.

Less than 30 weeks:
5 mg/kg/DOSE q48h.

30 to 35 weeks:
5 mg/kg/DOSE q36h.

36 weeks or greater:
5 mg/kg/DOSE q24h.

Exceptions to use of extended interval dosing: Renal dysfunction at baseline; consider alternate antibiotic
Synergistic dosing of aminoglycosides with beta-lactams; use conventional dosing.

All gestations, on indomethacin or renal impairment:
5 mg/kg/DOSE q36h.

Less than 36 weeks:
5 mg/kg/DOSE q24h.

36 weeks or greater:
6 mg/kg/DOSE q24h.