Tobramycin - General Pediatric Dosing

Exceptions to use of extended interval dosing: Renal dysfunction at baseline; consider alternate antibiotic
Synergistic dosing of aminoglycosides with beta-lactams; use conventional dosing.

1 month - 9 years

IV 9 mg/kg/DAY given as a single daily dose.

9+ Years

IV 7 mg/kg/DAY given as a single daily dose.

Cystic fibrosis (all ages):
IV 10 mg/kg/DAY given as a single daily dose.

Urinary tract infections (all ages):
IV 5 to 7 mg/kg/DAY given as a single daily dose.

Usual dose:
IV, IM: 2.5 mg/kg/DOSE every 8 hours.

Cystic fibrosis:IV, IM:
Usually require higher doses at 2.5 to 3.3 mg/kg/DOSE every 6 to 8 hours.

Synergistic dosing of aminoglycosides with beta-lactams:
Use low doses of IV, IM: 1 mg/kg/DOSE every 8 hours. Treatment of Enterococcus species may require synergistic therapy with a full dose of 2.5 mg/kg/DOSE every 8 hours.

Inhalational therapy in CF:
Children ≥6 years and Adolescents: 300 mg nebulized every 12 hours; in repeated cycles of 28 days on drug, followed by 28 days off drug.
Note dose varies with product use