Urinary tract infections, susceptible MRSA infections, Stenotrophomonas infections, Pneumocystis jirovecii pneumonia (treatment or prophylaxis)
Follow creatinine and electrolytes in patients at increased risk renal failure, hyperkalemia, CBC for cytopenias.
Stevens Johnson syndrome/toxic epidermal necrolysis, other rashes, gastrointestinal upset common, bone marrow suppression, hyperkalemia, renal failure, hepatitis, aseptic meningitis
Antimicrobial class: Sulfonamide - Antifolate
Average serum half life:
TMP (prolonged in renal failure)
SMX: 9-12 hours, prolonged in renal failure (Adult data)
Route of Elimination: Both excreted in urine as metabolites and unchanged drug