Vancomycin (PO) - General Pediatric Dosing

C. difficile-associated diarrhea (Infants, Children, and Adolescents): PO 40 mg/kg/DAY divided TID or QID for 7 to 10 days. Max 2000 mg/DAY.

For severe or recurrent infection (Oral, rectal enema): 40 mg/kg/DAY divided QID for ≥10 days; Max dose 2000 mg/day; if complete ileus, rectal enema dosage form may be preferable.

Note that therapeutic interchange for adults suggests dosing of 125 mg PO QID.