Voriconazole - General Pediatric Dosing

Optimal doses are unknown, but studies have demonstrated children require higher mg/kg doses compared with adults to achieve similar voriconazole exposure.
IV/PO: 9 mg/kg/dose every 12 hours; maximum single dose: 350 mg

Loading dose IV: 6 mg/kg/DOSE every 12 hours for 2 doses on Day 1

Maintenance dose IV: 4 mg/kg/DOSE every 12 hours

Oral dose (<40 kg): Optional loading dose of 200 mg/DOSE every 12 hours for 1 day followed by 100 mg/DOSE every 12 hours as maintenance; maximum 300 mg/day.

Oral dose (≥40 kg): Optional loading dose of 400 mg/DOSE every 12 hours for 1 day followed by 200 mg/DOSE every 12 hours as maintenance, Maximum 600 mg/day.