Antimicrobials
Oseltamivir

Oseltamivir

None
Excellent
PO : $$

Spectrum of Activity

General Information

Indicated for patients who are moderately or severely ill with influenza-like illness or at high risk for influenza related complications:

  • Cardiac or pulmonary disorder
  • Diabetes and other metabolic diseases
  • Cancer
  • Immunodeficiency/immunosuppression
  • Renal disease
  • Anemia or hemoglobinopathy
  • Healthy pregnant woman

Refer to BCCH oseltamivir algorithm on SHOP

Pre-exposure and post-exposure prophylaxis currently not recommended except in limited cases

Treatment of influenza

  • GI upset common, nausea and vomiting may be less severe if taken with food
  • Transient neuropsychiatric events (self-injury, delirium) have been reported in postmarketing surveillance, with the majority in pediatric populations
    • Monitor for abnormal behaviours
  • Capsule: 75mg, 30mg, 45mg
  • Suspension: 6 mg/mL (commercially available)
  • Greatest benefit is when oseltamivir is started within 48 hours of influenza illness onset, but may still be beneficial when administered > 48 hours
  • Capsules can be opened and mixed with sweetened liquids (chocolate syrup) or juice immediately prior to administration

Antimicrobial class: Antiviral - neuraminidase inhibitor

Route of Elimination: Hepatically metabolized to >99% of oseltamivir carboxylate (active metabolite) which is eliminated through urine; feces (<20%)