Pregnancy:
Breastfeeding:
Fungicidal therapy of yeast/fungus/mold infection (not for use in urinary tract infections)
Renal function, K, Mg, HCO3, liver enzymes, CBC.
Frequency depends on course, but daily reasonable during initiation
Concomitant nephrotoxins - use should be minimized during amphotericin therapy
Digoxin - increased digoxin toxicity with hypokalemia
Lipid associated AmB is taken up preferentially by phagocytic cells and concentrated at sites of infection while minimizing renal exposure.
Adequate hydration prior to infusion is recommended to reduce risk of nephrotoxicity.
Premedication with analgesics, antiemetics, antihistamines and hydrocortisone may be required for infusion related reactions. These reactions are usually more common with the first few doses and generally diminish with subsequent doses.
Antimicrobial class: Antifungal - polyene - Lipid formulations (designed to minimize toxicity)