Pregnancy:
Breastfeeding:
Infections caused by multi-drug resistant gram negative organisms including carbapenemase-producing organisms.
Consultation with infectious disease is strongly recommended.
Serum creatinine, urine output
Avoid in myasthenia gravis.
ALL DOSES FOR COLISTIN MUST BE EXPRESSED IN COLISTIN BASE. Colistin Base Activity (CBA) 1 mg is defined to be equivalent to colistimethate sodium (CMS) 30,000 units which is equivalent to ~2.4 mg CMS.
Antimicrobial Class: Colistimethate (or the sodium salt [colistimethate sodium]) is the inactive prodrug that is hydrolyzed to colistin, which acts as a cationic detergent and damages the bacterial cytoplasmic membrane causing leaking of intracellular substances and cell death
ALL DOSES FOR COLISTIN MUST BE EXPRESSED IN COLISTIN BASE. Colistin Base Activity (CBA) 1 mg is defined to be equivalent to colistimethate sodium (CMS) 30,000 units which is equivalent to ~2.4 mg CMS.