Antimicrobials
Amphotericin B Deoxycholate

Amphotericin B Deoxycholate

Low
N/A

Spectrum of Activity

Dosing

General Information

HEALTH CANADA APPROVED

  • Treatment of disseminated mycotic infections

Known hypersensitivity to amphotericin B or any component of the formulation unless the benefits outweigh the risks

  • Neuromuscular blocking agents, digoxin, antiarrhythmics: amphotericin induced hypokalemia may enhance effects and/or toxicity
  • Other nephrotoxic drugs: Concomitant use may enhance amphotericin B nephrotoxicity (eg vancomycin, aminoglycosides, pentamidine, cycloSPORINE, CISplatin)
  • Loop/thiazide diuretics, long term steroids, laxatives; increased risk for hypokalemia/hypomagnesemia; recommend amiloride. Monitor potassium closely. May still need additional potassium supplementation

RECOMMENDED

  • Baseline serum creatinine, serum electrolytes (including calcium and magnesium), complete blood count with differential, then weekly
  • Baseline AST, alkaline phosphatase and bilirubin, then weekly
  • Monitor volume status and weight throughout therapy to prevent sodium depletion and dehydration

IM and subcutaneous administration: not applicable

Antimicrobial class: Antifungal. Polyene

Pregnancy category: B

Average serum half life: 24 hours

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Therapeutic