Antimicrobials
Probenecid

Probenecid

Dosing

General Information

Used to prolong beta-lactam serum levels to facilitate outpatient use of intravenous antibiotics, usually cefazolin

Avoid concomitant use of probenecid and methotrexate if possible. Can increase levels of methotrexate.

Not covered under PEI Pharmacare.

  • Allergic reactions including anaphylaxis
  • May cause exacerbation of gout
  • Gastrointestinal upset, may administer with food to minimize GI effects