Antimicrobials
Fidaxomicin (Dificid®)

Fidaxomicin (Dificid®)

Restricted

None
None

Spectrum of Activity

Dosing

General Information

C. difficile colitis

Restriction: Restricted to ID expert or designee

Criteria for Use:

  • Severe Clostridium difficile infection (CDI) in patients with a 2nd recurrence, who previously received vancomycin PO for initial and 1st recurrence
  • Mild-moderate CDI in patients with a 3rd recurrence, who previously received vancomycin therapy for initial and 1st recurrence and then a vancomycin taper for the 2nd recurrence

Unacceptable Uses:

  • Treatment of systemic infections
  • Treatment of severe, complicated CDI (i.e., life-threatening or fulminant CDI or toxic megacolon)

Advisory: Not to be used in combination with PO vancomycin or PO/IV metronidazole

  • GI disturbance
  • Cytopenias
  • Hypersensitivity: facial, tongue or throat swelling

Consult Infectious Disease

Antimicrobial class: Specialized anti-C. difficile macrocyclic agent

Pregnancy category: B

Biliary penetration: None

CSF penetration: None

Lung penetration: None

Urine penetration: None