Restricted
Therapy of serious, often nosocomial infections involving resistant gram negative organisms.
Restriction: Restricted to ID expert or designee
Criteria for Use:
Advisory: Extended-infusion dosing over 3 hours has been utilized
Valproic acid - Carbapenems decrease valproate levels and may decrease seizure threshold.
Antimicrobial class: Carbapenem
Pregnancy category: B
Average serum half life: 1 hour
Biliary penetration: Therapeutic
CSF penetration: Moderate
Lung penetration: Therapeutic
Urine penetration: Therapeutic