Antimicrobials
Tobramycin

Tobramycin

Low
N/A
IV: $$

Spectrum of Activity

General Information

ODB Covered (injection, opth oint/suspension)

  • Nephrotoxicity (non-oliguric) - less common with once daily dosing; greater toxicity with longer duration and supratherapeutic trough levels; avoid concomitant nephrotoxins
  • Vestibulocochlear toxicity (irreversible) - require audiology testing if prolonged use
  • Can exacerbate neuromuscular blockade - e.g. contraindicated in patients with myasthenia gravis
  • Calculate dose according to adjusted body weight

    • Adjusted Body Weight (ABW)(kg) = IBW + 0.4 (actual body weight - IBW)
  • Peripheral venous sampling for tobramycin levels to be done in patients on concurrent inhaled and intravenous tobramycin