Endocarditis or bloodstream infection
6-10 mg/kg IV daily
4 mg/kg IV daily
CrCl Greater Than 30 mL/minCrCl Less Than 30 mL/minRegular dosingGive dose q48h
Dose as in creatitine clearance less than 30 mL/min. Give dose after HD on dialysis days.
8mg/kg IV q48h
Creatine kinase weekly
GI side effects common
Myopathy including rhabdomyolysis
Statins and fibrates - Increased myopathy. Monitor creatine kinase or hold while on daptomycin therapy.
Higher doses used for endovascular infection.
Recommend Infectious Disease Consult.
Inactivated by pulmonary surfactant and therefore insufficient for pulmonary infection.
Antimicrobial class: Cyclic Lipopeptide
Pregnancy category: B
Average serum half life: 9 hours
CSF penetration: Poor
Lung penetration: Poor
Urine penetration: Therapeutic
Targeted therapy of resistant gram positive infections with MRSA (particularly when MIC≥2) and VRE including endovascular infection