DAPTOmycin

C. diff Risk

Low

Oral Bioavailability

NA

Approximate Cost

Non-formulary

Spectrum Of Activity

Dosing

Endocarditis or bloodstream infection
6-10 mg/kg IV daily

Non-bloodstream infections
4 mg/kg IV daily

CrCl Greater Than 30 mL/minCrCl Less Than 30 mL/minRegular dosingGive dose q48h

Dose as in creatitine clearance less than 30 mL/min. Give dose after HD on dialysis days.

8mg/kg IV q48h

General Information

Creatine kinase weekly

  • GI side effects common

  • Rash

  • Phlebitis

  • Increased INR

  • Myopathy including rhabdomyolysis

Statins and fibrates - Increased myopathy. Monitor creatine kinase or hold while on daptomycin therapy.

Higher doses used for endovascular infection.

Recommend Infectious Disease Consult.

Inactivated by pulmonary surfactant and therefore insufficient for pulmonary infection.

Antimicrobial class: Cyclic Lipopeptide

Pregnancy category: B

Average serum half life: 9 hours

CSF penetration: Poor

Lung penetration: Poor

Urine penetration: Therapeutic

Targeted therapy of resistant gram positive infections with MRSA (particularly when MIC≥2) and VRE including endovascular infection