Penicillin G

C. diff Risk


Oral Bioavailability



12-24 million units/day IV in 6 divided doses

Discuss indication specific dose recommendations with ID or ASP

CrCl Greater Than 50 mL/minCrCl 10-49 mL/minCrCl Less Than 10 mL/min1-4 million units q4-6h1-4 million units q8-12h1-4 million units q12h

Discuss indication specific renal dose adjustments with ID or ASP

General Information

  • Allergy/rash (immediate or delayed)

  • Seizures

  • Cytopenias

  • Eosinophilia

  • Interstitial nephritis

  • Abnormal liver enzymes

  • Serum sickness

Antimicrobial class: Penicillin

Pregnancy category: B

Average serum half life: 1 hour

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Moderate

Biliary penetration: Therapeutic

Therapy of Streptococcal and other documented susceptible infections.