1-2g IV q8-12h
CrCl Greater Than 60 mL/minCrCl 30-50 mL/minCrCl 11-29 mL/minCrCl Less Than 11 mL/min2 g IV q8-12h2g IV q12-24h1-2g IV q24h500mg-1g IV q24h
Allergy (immediate & delayed)
Non-convulsive status epilepticus (resolves with discontinuation of cefepime)
Elevated liver function tests
Infusion related reactions, including red man syndrome have been reported
Antimicrobial class: 4th generation Cephalosporin
Pregnancy category: B
Average serum half life: 2 hours
Biliary penetration: Moderate
CSF penetration: Therapeutic
Lung penetration: Therapeutic
Urine penetration: Therapeutic
Broad spectrum antimicrobial with gram positive and gram negative coverage including Pseudomonas.
Used especially nosocomial infections involving resistant organisms.
Cefepime is non-formulary at MSH.