Antimicrobials
Piperacillin-Tazobactam

Piperacillin-Tazobactam

Medium
N/A

Dosing

General Information

Broad spectrum agent with anti-pseudomonal activity.

Used for severe infections including:

  •  Pneumonia
  •  Intra-abdominal/hepatobiliary
  •  UTI
  •  Polymicrobial skin and soft tissue infection
  •  Febrile neutropenia
  • Allergy/rash (immediate or delayed)
  • Cytopenias- esp. thrombocytopenia
  • Eosinophilia
  • Interstitial nephritis
  • Abnormal liver enzymes

Avoid use with intravesicular BCG, Typhoid vaccine and Cholera vaccine due to decreased effect.

Increased levels of:

  • methotrexate
  • vancomycin
  • Vecuronium
  • Warfarin/Vitamin K antagonists

Decreased levels of:

  • aminoglycosides
  • mycophenolate

May result in false positive Coomb's test. Tetracyclines may decrease levels of Piperacillin-Tazobactam.

Antimicrobial class: Ureidopenicillin with a beta-lactamase inhibitor

Pregnancy category: B

Average serum half life: 1 hour

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Poor overall CSF penetration. Moderate CNS penetration with inflamed meninges, may not be effective for P. aeruginosa.

Biliary penetration: Therapeutic