Broad spectrum agent with anti-pseudomonal activity.
Used for severe infections including:
Avoid use with intravesicular BCG, Typhoid vaccine and Cholera vaccine due to decreased effect.
Increased levels of:
Decreased levels of:
May result in false positive Coomb's test. Tetracyclines may decrease levels of Piperacillin-Tazobactam.
Antimicrobial class: Ureidopenicillin with a beta-lactamase inhibitor
Pregnancy category: B
Average serum half life: 1 hour
Urine penetration: Therapeutic
Lung penetration: Therapeutic
CSF penetration: Poor overall CSF penetration. Moderate CNS penetration with inflamed meninges, may not be effective for P. aeruginosa.
Biliary penetration: Therapeutic