C. diff Risk


Oral Bioavailability



1-2g IV q8h

CrCl Greater Than 50 mL/min
1-2 g q8hCrCl 25-49 mL/min
1-2 g q12hCrCl 10-24 mL/min
1-2 g q24hCrCl Less Than 10 mL/min
500 mg-1 g q24h

General Information

Allergy (immediate and delayed).

Note potential cross-reactivity with aztreonam based on side chain.

Antimicrobial class: 3rd generation Cephalosporin

Pregnancy category: B

Average serum half life: 2 hours

Biliary penetration: Moderate

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic

Broad gram negative coverage including Pseudomonas, generally used for nosocomial infections including post-neurosurgical meningitis, or other infections based on susceptibilities.

Notable lack of gram positive activity versus other cephalosporins.