1-2g IV q8h
CrCl Greater Than 50 mL/min
1-2 g q8hCrCl 25-49 mL/min
1-2 g q12hCrCl 10-24 mL/min
1-2 g q24hCrCl Less Than 10 mL/min
500 mg-1 g q24h
Allergy (immediate and delayed).
Note potential cross-reactivity with aztreonam based on side chain.
Antimicrobial class: 3rd generation Cephalosporin
Pregnancy category: B
Average serum half life: 2 hours
Biliary penetration: Moderate
CSF penetration: Therapeutic
Lung penetration: Therapeutic
Urine penetration: Therapeutic
Broad gram negative coverage including Pseudomonas, generally used for nosocomial infections including post-neurosurgical meningitis, or other infections based on susceptibilities.
Notable lack of gram positive activity versus other cephalosporins.