Caspofungin

C. diff Risk

Low

Oral Bioavailability

NA

Spectrum Of Activity

Dosing

70 mg IV once then 50 mg IV daily

Mild Impairment (Child-Pugh Class A):Moderate Impairment (Child-Pugh Class B):Severe Impairment (Child-Pugh Class C):No adjustment required70 mg IV once then 35 mg IV dailyThe manufacturer provides to dosing guideline. Not studied.

General Information

  • ¬†Increased liver enzymes

  • ¬†GI upset

Decreases levels of Tacrolimus
Cyclosporine may increase levels of Caspofungin
Rifampin may decrease Caspofungin concentrations

Antimicrobial class: Echinocandin

Pregnancy category: C

Average serum half life: 10 hours

Biliary penetration: Therapeutic

CSF penetration: Poor

Lung penetration: Therapeutic

Urine penetration: Poor

Therapy of suspected and confirmed invasive fungal infections