Nitrofurantoin

C. diff Risk

Low

Oral Bioavailability

Moderate

Dosing

Cystitis
Macrobid 100 mg PO BID

CrCl Greater Than 30 mL/minCrCl Less Than 30 mL/min100 mg PO BIDNitrofurantoin should be avoided

General Information

Interstitial pneumonitis and fibrosis especially with prolonged use.

Peripheral neuropathy.

Antacids decrease absorption

Think of this drug as a urinary antiseptic.

Not recommended in males due to inadequate tissue penetration, especially with possible occult prostatitis.

Antimicrobial class: Nitrofuran

Pregnancy category: B (Contraindicated at term)

Average serum half life: 1 hour

Biliary penetration: None

CSF penetration: None

Lung penetration: None

Urine penetration: Therapeutic

Uncomplicated cystitis in females with normal renal function