Oseltamivir

C. diff Risk

None

Oral Bioavailability

Excellent

Spectrum Of Activity

Dosing

15 kg and underOver 15 kg to 23 kg inclusiveOver 23 kg to 40 kg inclusiveOver 40 kg30 mg po BID45 mg po BID60 mg po BID75 mg po BID

3 mg/kg/dose po BID

Influenza treatment
75 mg PO BID x 5 days

Prophylaxis
75 mg PO daily

CrCl Greater Than 60 mL/minCrCl 31-60 mL/minCrCl 10-30 mL/minCrCl Less Than 10 mL/min75 mg BID30 mg BID30 mg dailySingle 75mg dose for the duration of illness

CrCl Greater Than 60 mL/minCrCl 31-60 mL/minCrCl 10-30 mL/minCrCl Less Than 10 mL/min75 mg daily30 mg daily30 mg every second dayNot recommended

General Information

  • GI upset common

  • Rare - Stevens Johnson

  • Neuropsychiatric side effects reported

No significant interactions

Antimicrobial class: Antiviral - Neuraminidase inhibitor

Pregnancy category: C

Average serum half life: 2 hours

Lung penetration: Therapeutic

Treatment and prophylaxis of influenza