Meropenem

C. diff Risk

Medium

Oral Bioavailability

NA

Dosing

Standard Dose
500mg IV q6h or 1g IV q8h

Meningitis
2g IV q8h

CrCl Greater Than 50 mL/minCrCl 30-49 mL/minCrCl 10-29 mL/minCrCl Less Than 10 mL/min500 mg q6h500 mg q8h500 mg q12h500 mg q24h

CrCl Greater Than 50 mL/minCrCl 26-50 mL/minCrCl 10-25 mL/minCrCl Less Than 10 mL/min2 g IV q8h2 g IV q12h1 g IV q12h1 g IV q24h

General Information

  •  Immediate and delayed-type allergy

  •  GI disturbance

  •  Cytopenias, positive Coombs

  •  Liver enzyme abnormalities

Valproic acid - Carbapenems decrease valproate levels and may decrease seizure threshold.

Antimicrobial class: Carbapenem

Pregnancy category: B

Average serum half life: 1 hour

Biliary penetration: Therapeutic

CSF penetration: Moderate

Lung penetration: Therapeutic

Urine penetration: Therapeutic

Therapy of serious, often nosocomial infections involving resistant gram negative organisms.