C. diff Risk


Oral Bioavailability


Spectrum Of Activity


250-500 mg po TID. Some guidelines may recommend higher dosing.

CrCl Greater Than 30 mL/minCrCl 10-30 mL/minCrCl Less Than 10 mL/min250-500 mg TID250-500 mg BID250-500 mg q24h

General Information

  •  Allergy/rash (immediate or delayed)

  •  Note EBV related rash

  •  Cytopenias

Allopurinol - increased rash

Antimicrobial class: Aminopenicillin

Pregnancy category: B

Average serum half life: 1 hour

Biliary penetration: Therapeutic

CSF penetration: Moderate with inflamed meninges only

Lung penetration: Therapeutic

Urine penetration: Therapeutic

Therapy of Streptococcal and Enterococcal infections as well as susceptible gram negative infections.

Commonly used for upper respiratory infections and urinary tract infections.