Oral antimicrobial has rapid absorption and high oral bioavailability systemically, that is comparable to IV administration route.
Antimicrobials with excellent oral bioavailability should be given PO as long as the patient is stable, has a functioning gastrointestinal tract and there are no drug or food interactions with the enteral form.
Patient with exclusions referenced on the previous screen, should NOT receive oral anitmicrobials.
Bioavailability: 37% - Azithromycin rapidly moves into tissues resulting in low serum concentrations, but high and persistent tissue concentrations, which makes it suitable for an IV to PO conversion.
IV Dose | PO Dose |
---|---|
250 mg q24h | 250 mg q24h |
500 mg q24h | 500 mg q24h |
Note: Do not administer via jejunostomy tube (J-tube) as it bypasses the main site of absorption. Do not use ciprofloxacin with any tube as it may clog them.
Bioavailability: 70-89%
IV Dose | PO Dose |
---|---|
400 mg q12h | 500 mg q12h |
400mg q8h | 750mg q12h |
Bioavailability: 90%
IV Dose | PO Dose |
---|---|
600-900 mg q8h | 300-450 mg q6h-q8h |
Bioavailability: Greater than 90%
IV Dose | PO Dose |
---|---|
100 mg q12h | 100 mg q12h |
Bioavailability: Greater than 90%
IV Dose | PO Dose |
---|---|
100mg q24h | 100mg q24h |
150mg q24h | 150mg q24h |
200 mg q24h | 200 mg q24h |
400 mg q24h | 400 mg q24h |
800 mg q24h | 800 mg q24h |
Bioavailability: 100%
IV Dose | PO Dose |
---|---|
600 mg q12h | 600 mg q12h |
Bioavailability: 100%
IV Dose | PO Dose |
---|---|
500 mg q8h | 500 mg q8h |
500 mg q12h | 500 mg q12h |
Bioavailability: 90%
IV Dose | PO Dose |
---|---|
400 mg q24h | 400 mg q24h |
Note Dose variable based on indication
Bioavailability: 90-100%
IV Dose 10 mL q6h of TRIMETHOPRIM 160 mg/mL and SUFAMETHOXAZOLE 800 mg/mL injection
PO Dose 1 DS q12h
Bioavailability: 96%
IV Dose | PO Dose |
---|---|
200 mg (4mg/kg) q12h | 200 mg q12h |