Pseudomonal and other gram negative infections of urinary tract, bone/joint, abdomen, and other sites
For uncomplicated infections consider alternative agents
Laboratory
Clinical
CYP inhibitor - multiple interactions possible
QTc prolongation - Increased risk with other agents that prolong QTc
Di- & Trivalent cations including Al, Ca, Fe, Mg (antacids, dairy products, iron supplements, some enteral feeds) - decreased absorption
Cyclosporine - increased levels of cyclosporine
Warfarin - increased INR
Methadone - lowered seizure threshold
Ciprofloxacin is associated with arthropathy and histological changes in weight-bearing joints of juvenile animals and is currently not FDA approved for pediatric use.
Antimicrobial class: Fluoroquinolone
Pregnancy category: C
Average serum half life: 4 hours
Biliary penetration: Therapeutic
CSF penetration: Moderate
Lung penetration: Therapeutic
Urine penetration: Therapeutic