Ciprofloxacin
Renal - Adult

Renal - Adult

Notes

  • Highly bioavailable, switch IV to PO when stable or taking orals
  • Avoid concomitant PO administration with divalent or trivalent cations (i.e.Ca/Mg/Fe supplements)
  • Infectious Diseases Pharmacy: RRMC p99917; SMH p91059

Pseudomonas/Deep-seated Infections

CrCl <30 mL/min (ESRD not on HD)

750 PO Q24h or 400 mg IV Q12h

Dialysis (HD)

500 mg or 400 mg IV Q24h post-HD on HD days

Other indications

CrCl < 30 mL/min (ESRD not on HD)

500 mg PO Q24h or 400 mg IV Q24h

Dialysis (HD)

500 mg PO or 400 mg IV Q24h post-HD on HD days

CVVHD

<2L/hr

400 mg x1, then 400 mg IV Q12h

2 to 4L/hr

400 IV Q8

> 4L/hr

Page Infectious Diseases Pharmacy; TDM Suggested