Antimicrobials
Ertapenem

Ertapenem

Medium
N/A
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General Information

  • Mild to moderate intra-abdominal infections (biliary tract infections, diverticulitis, secondary peritonitis/GI perforation)
  • Moderate diabetic foot infections
  • Moderate surgical-site infections following contaminated procedures
  • Urinary tract infections caused by ESBL-producing organisms
  • Pyelonephritis due to ESBL-producing organisms
  • Outpatient antibiotic therapy for patients requiring IV antibiotics for polymicrobial infections caused by susceptible organisms
  • Infections in which Pseudomonas spp. or Acinetobacter spp. are suspected

Targeted therapy of ESBL infections and other resistant gram negative infections

Empiric therapy when broad spectrum of carbapenems is desired without the need for antipseudomonal activity

Laboratory

  • CBC, CMP weekly

Clinical

  • Hypersensitivity
  • GI effects
  • Seizures (rare)
  • Hypersensitivity
  • GI effects
  • C. difficile
  • Seizures (especially with high doses or doses not adjusted for renal function)

Antimicrobial class: Carbapenem

Pregnancy category: B

Average serum half life: 4 hours

Biliary penetration: Moderate

Lung penetration: Therapeutic

Urine penetration: Therapeutic