Antimicrobials
Fosfomycin

Fosfomycin

Low
Moderate
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Spectrum of Activity

Dosing

General Information

  • Management of uncomplicated UTI in patients with multiple antibiotic allergies and when oral therapy is indicated.
  • Uncomplicated UTI due to VRE in patients with documented penicillin allergy.
  • Salvage therapy for UTI due to multidrug-resistant organisms (e.g. ESBL, VRE, ±Pseudomonas) on a case by case basis.
  • Never use fosfomycin for management of infections outside the urinary tract because the oral formulation does not achieve adequate concentrations at other sites.

Urinary Tract Infection, especially involving ESBL producing organisms

Off label - prostatitis; extended course. Caution advised due to lack of data in long-term use and in prostatitis.

Not recommended in pyelonephritis

  • GI upset, esp. diarrhea
  • Headache
  • Eosinophilia, neutropenia
  • Hypokalemia
  • IV formulation not available in the United States

Antimicrobial class: Phosphonic acid derivative

Pregnancy category: B

Average serum half life: 6 hours

Urine penetration: Therapeutic