Ampicillin-Sulbactam

C. diff Risk

Medium

Oral Bioavailability

NA

Approximate Cost

$$

Dosing

1.5 - 3 g IV q6-8h

Higher doses may be used for infections due to MDR Acinetobacter spp.

CrCl > 50 mL/minCrCl 10 - 50 mL/minCrCl < 10mL/min (ESRD not on HD)3 g IV Q6h3 g IV Q8h3 g IV Q12h

Dialysis (HD)Dialysis (CRRT)3g IV Q12-24h3g IV Q8-12h

Creatinine Clearance >50mL/min/1.73m²Creatinine Clearance 15-30mL/min/1.73m²Creatinine Clearance ≤10mL/min/1.73m²50mg ampicillin/kg/dose Q6H50mg ampicillin/kg/dose Q12H50mg ampicillin/kg/dose Q24H

2g ampicillin Q6H

General Information

Treatment of:

  • human or animal bites if parenteral therapy is needed

  • oral infections

  • lung abscess

  • culture-negative endocarditis (ID consult advised)

  • multi-drug resistant (MDR) Acinetobacter spp. (ID consult advised)

  • Empiric treatment of biliary tract infections, diverticulitis, or secondary/peritonitis/GI perforation.

  • Use should be limited to infections that are proven to be susceptible.