Spectrum Of Activity
PNA-days 0 - 14PNA-days 15 - 28IV: 20 mg/kg/dose every 12 hoursIV: 20 mg/kg/dose every 8 hours
PNA-days 0 - 7PNA-days 8 - 28IV: 20 mg/kg/dose every 12 hoursIV: 20 mg/kg/dose every 8 hours
IV: 20 mg/kg/dose every 8 hours
0 - 3 months 60mg/kg/DAY divided q8h
3 months - 12 years 12 years+ 30-45mg/kg/DAY divided q8h30mg/kg/DAY divided q8h
15mg/kg/DAY divided q8h
30mg/kg/DAY divided q8h
HSV prophylaxis: 300mg/m2/DOSE q8hHSV mucocutaneous inf: 40-80mg/kg/DAY divided q6-8hVaricella: 80mg/kg/DAY divided q6h
Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing.
Therapy for herpesviral infections (HSV and VZV) including encephalitis
Prophylaxis of herpesviral infections if recurrent disease or immunocompromised
Follow SCr, BUN, urine output as appropriate, liver enzymes and CBC.
Liver or renal dysfunction
Crystal nephropathy (keep patient well hydrated)
- May diminish efficacy of zoster or varicella vaccine.
- For oral indications, Valacyclovir is the pro-drug and is more bioavailable with more convenient dosing.
Antimicrobial class: Antiviral, nucleoside analogue
Average serum half life: Neonates: 4 hours
Children 1-12 years: 2-3 hours
Route of Elimination: Primarily kidney with 60-90% of drug excreted unchanged in the urine