Cefazolin

C. diff Risk

Medium

Oral Bioavailability

NA

Approximate Cost

$5/day

Dosing

IV, IM 50mg/kg/DAY divided q12h.

PNA-days 0 - 7PNA-days 8 - 28IV, IM 50mg/kg/DAY divided q12hIV, IM 75 mg/kg/DAY divided q8h

IV, IM 50–100mg/kg/DAY divided q8h.
Max 2g/dose

IV, IM 100-150mg/kg/DAY divided q8h.
Max 2g/dose

Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing.

General Information

Adverse Effects

Allergy (immediate or delayed).

Can cause positive Coombs, cytopenias.

Major Interactions

Probenecid - prolonged half-life. Drug interaction has been used therapeutically to give once daily cefazolin

Pharmacology

Antimicrobial class: 1st Generation Cephalosporin

Average serum half life: Neonates: 3-5 hours
Adults: 1.8 hours

Route of Elimination: excreted unchanged in urine

Common Usage

Skin and soft tissue infection (i.e. cellulitis).

Surgical prophylaxis.

Susceptible Staphylococcal, Streptococcal and Gram negative infections.