Cefuroxime

C difficile risk
Medium
Oral Bioavailability
Excellent
Cost
IV-15$/d PO-4$/d

Dosing

0 - 2 kg2+ kgIV 50mg/kg/DOSE q12hIV 50mg/kg/DOSE q12h

0 - 2 kg2+ kgIV 50mg/kg/DOSE q8-12h.IV 50mg/kg/DOSE q8h.

75-100mg/kg/DAY divided q8h. Max:1500mg/dose

20-30mg/kg/DAY divided q12h. Max:500mg/dose

100-200mg/kg/DAY divided in q6-8h. Max:1500mg/dose

Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing.

General Information

Community acquired pneumonia

Allergy (immediate & delayed), positive Coombs, cytopenias, GI upset, diarrhea, abnormal liver enzymes

Antimicrobial class: 2nd Generation Cephalosporin

Average serum half life: Neonates: PNA≤3 days median 5.8 hours.<br> PNA ≥8 median 1.6-3.8 hours.<br> Pediatrics: 1.4-1.9 hours.

Route of Elimination: 66-100% as unchanged drug in urine by both glomerular filtration and tubular secretion