Antimicrobials
Micafungin

Micafungin

Low
N/A
$100/day

Spectrum of Activity

General Information

Therapy of suspected and confirmed invasive fungal infections

Periodic liver function tests, renal function tests, CBC with differential

Increased liver enzymes, elevated bilirubin

GI upset

Anemia, pruritis, fever (most common in pediatrics)

Increases levels of sirolimus

Antimicrobial class: Echinocandin

Average serum half life: • Neonates: PNA <1week: 6.7 hours. PNA >3 weeks: 5.6-11 hours.

  • Pediatrics: ≤30 kg: 12.5 ± 4.6 hours. >30kg: 13.6 ± 8.8 hours
  • Healthy adults: 11-21 hours

Route of Elimination: <1% of dose is eliminated unchanged in the urine. 71% is eliminated in the feces