Piperacillin-Tazobactam

C difficile risk
Medium
Oral Bioavailability
N/A
Cost
$30/day

Dosing

Dosing is expressed in mg piperacillin component.

Note dosing is expressed in mg piperacillin component.Usual Dose: Infants less than 6 months: IV 150 to 300 mg/kg/DAY, divided q6-8hUsual Dose: Infants and children 6 months and older: IV 240 to 300 mg/kg/DAY, divided q6-8h.

PNA-days 0 - 7PNA-days 8 - 28200 mg/kg/DAY divided q12h300 mg/kg/DAY divided q8h

Ratio of piperacillin : tazobactam components is 80:1

Serious/ documented pseudomonal infections: IV 300 to 400 mg/kg/DAY, divided q6-8h. Max dose: 16 g piperacillin/DAY.

No dosage adjustment necessary.

Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing.

General Information

Broad spectrum agent with anti-pseudomonal activity used for severe infections including pneumonia, intra-abdominal/hepatobiliary, UTI, polymicrobial skin and soft tissue infection, and febrile neutropenia

Renal and hepatic function, CBC with differential, C. difficile-associated diarrhea, hypersensitivity reactions and IV site for phlebitis.

Allergy/rash (immediate or delayed), cytopenias - esp. thrombocytopenia, eosinophilia, interstitial nephritis, abnormal liver enzymes