Rifampin

C. diff Risk

Low

Oral Bioavailability

Good (70 to 90%)

Spectrum Of Activity

Dosing

Staphylococcal infections (ONLY in combination with other antibiotics)Meningitis Prophylaxis N.Meningitidis Nova Scotia Communicable Diseases ManualAtypical mycobacterial cervical lymphadenitisTuberculosis20 mg/kg/24h divided PO once to twice daily
Maximum: 600 mg/24h
10 mg/kg/dose PO BID for 2 days

Maximum: 600 mg/dose10-20 mg/kg/24h divided PO once to twice daily
Maximum: 600 mg/24h

Staphylococcal infections (ONLY in combination with other antibiotics)Meningitis Prophylaxis N.Meningitidis Nova Scotia Communicable Diseases Manual
Oral
10-20 mg/kg/24h divided PO once to twice daily

Intravenous
5-10 mg/kg/dose IV every 12 hours 5 mg/kg/dose PO BID for 2 days

General Information

Adverse Effects

*Nausea, vomiting, loss of appetite, stomach cramps, gas,and diarrhea. Best absorbed on an empty stomach but GI AEs may be relieved by taking
with a small meal.
*Red-orange discolouration of urine, stools, saliva, lung
secretions, sweat, tears, and skin. Caution with contact lenses.
*Increase liver enzymes. (usually asymptomatic), rarely hepatitis (yellowing of the eyes and skin, dark urine, fever, nausea and /
or vomiting, pale stools, fatigue, and abdominal pain.
* Neutropenia and thrombocytopenia (rare)

Major Interactions

Interacts with many other drugs, especially those that are eliminated by the liver. Please consult a clinical pharmacist.

Oral Liquids

Concentration: 25 mg/mL (IWK Compounded)

Tablet/Capsule Strengths

Capsule: 150 mg, 300 mg

Additional Information

Food decreases the extent of absorption; rifampin concentrations may be decreased if taken with food. Management: Administer on an empty stomach. May be taken with a small amount of food if GI intolerance occurs.