Zidovudine

C. diff Risk

NA

Oral Bioavailability

NA

Dosing

IV Dosing only if unable to tolerate oral therapySwitch to oral therapy when neonate almost reaches full feeds

Greater than or equal to 35 weeks30 to 34 weeksLess than 30 weeksFor 6 weeks:

  • 4 mg/kg/dose PO q12h OR

  • 3 mg/kg/dose IV q12hFirst 2 weeks:

  • 2 mg/kg/dose PO q12h OR

  • 1.5 mg/kg/dose IV q12h

Then increase dose for final 4 weeks:

  • 3 mg/kg/dose PO q12h OR

  • 2.3 mg/kg/dose IV q12hFirst 4 weeks:

  • 2 mg/kg/dose PO q12h OR

  • 1.5 mg/kg/dose IV q12h

Then increase dose for final 2 weeks:

  • 3 mg/kg/dose PO q12h OR

  • 2.3 mg/kg/dose IV q12h

General Information

Common Usage

For prophylaxis in HIV-Exposed Infant

Oral Liquids

Concentration: 10 mg/mL

Taste: Good

Not all strengths of oral liquids are listed nor are available on IWK formulary.