ceftaZIDime

C. diff Risk

High

Oral Bioavailability

NA

Approximate Cost

$18/day

Dosing

50 mg/kg/dose IV q12h

Post natal age 0 to 7 daysPost natal age greater than 8 days 50 mg/kg/dose IV q12h50 mg/kg/dose IV q8h

Post natal age 0 to 7 daysPost natal age greater than 8 days 50 mg/kg/dose IV q8-12h50 mg/kg/dose IV q8h

Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing.

General Information

Common Usage

Broad gram negative coverage including Pseudomonas, generally used for febrile neutropenia, or other infections based on susceptibilities.

Notable lack of gram positive activity versus other cephalosporins

Adverse Effects

Allergy (immediate and delayed)

Pharmacology

Antimicrobial class: 3rd generation Cephalosporin

Average serum half life:

  • neonates <23 days: 2.2-4.7 hours

  • adults: 1-2 hours

Route of Elimination: by glomerular filtration with 80-90% of dose excreted as unchanged drug in urine within 24 hours.