Antimicrobials
Amphotericin B liposomal (Ambisome)

Amphotericin B liposomal (Ambisome)

Low
N/A
$500+/day

Spectrum of Activity

General Information

  • Fungicidal therapy of yeast/fungus/mould infection (not for use in urinary tract infection)
  • Invasive candidiasis, aspergillosis, cryptococcosis
  • Visceral/mucocutaneous Leishmaniasis
  • Renal function
  • Fluid status
  • Serum electrolytes (K, Mg)
  • Liver enzymes
  • CBC with differential
  • Infusion related symptoms: fever/rigors/nausea/vomiting/headache
  • Electrolyte abnormalities - hypokalemia and hypomagnesemia, loss of bicarbonate
  • Nephrotoxicity ++
  • Anemia
  • Phlebitis
  • Paresthesias

Enhance nephrotoxic effect with concomitant use of other nephrotoxins - use should be minimized during amphotericin therapy.

Lipid formulations of AmB (Ambisome, Abelcet) are NOT interchangable

Antimicrobial class: Antifungal - polyene - Lipid formulations (designed to minimize toxicity)

Average serum half life: 

  • No pediatric data.
  • Liposomal: Adults: 100-153 hours (terminal half life)

Route of Elimination: Effects of hepatic and renal impairment on drug disposition are unknown