C. diff Risk


Oral Bioavailability


Approximate Cost



1-2 g IV q6h

2 g IV X 1 dose then 1 g IV q6h until delivery

Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing.

General Information

Common Usage

Pathogen directed therapy for CNS, intravascular, intraabdominal, urinary and other infections esp enterococcus and listeria. As part of empiric therapy for early onset sepsis in neonates.

Drug Monitoring

  • Renal

  • Liver function

  • CBC with differential

Adverse Effects

  • Allergy and rash

  • EBV related rash (not allergy)

  • Rare: cytopenias, +ve Coombs


Antimicrobial class: Aminopenicillin

Average serum half life:

  • Neonates
    PNA 2-7days: 4 hours
    PNA 8-14 days: 2.8 hours
    PNA 15-30 days: 1.7 hour

  • Pediatrics: 1-1.8 hours

  • Anuric patients: 8-20 hours

Route of Elimination:

  • 90% excreted unchanged in urine within 24 hours

  • Excreted in bile.