C. diff Risk


Oral Bioavailability


Approximate Cost



Ceftriaxone is preferred over cefotaxime in infants greater than 1 month of age100-200 mg/kg/24h IV divided q6-8h
Maximum: 2000 mg/dose OR 12 g/24h

50-75 mg/kg/dose IV q6h
Maximum: 2000 mg/dose

Renally cleared, requires dosage adjustment with changes in renal function. Consult a pharmacist for renal dosing.

General Information

Common Usage

Empiric therapy for bacterial meningitis, pneumonia, intra-abdominal infection (with metronidazole), and urinary tract infection

Adverse Effects

  • Rash

  • Localized phlebitis at injection site

  • Allergy

  • Positive Coombs test

  • Neutropenia

  • Diarrhea

Additional Information

Preferred cephalosporin in neonates


Antimicrobial class: 3rd Generation Cephalosporin

Average serum half life:

  • Neonates: 3.4-4.6 hours

  • Children: 1.5 hours

Route of Elimination: urine: ~60% as unchanged drug and metabolites in urine